![]() To be blunter, it appears UBX0101 probably won't deliver a therapeutic benefit to individuals with osteoarthritis of the knee. ![]() It needs to generate more data before investors start dreaming of halting age-related diseases. To be blunt, Unity Biotech got off to a messy start in the clinic. In part B - the part of the study without any significant difference from the placebo - half of the samples collected demonstrated that biomarkers were altered consistent with what might be expected if UBX0101 eliminated aging cells. In part A - the part of the study with "clinically meaningful" pain reduction scores - there were insufficient samples available to measure biomarkers. Unity Biotech moved beyond subjective measurements of pain and stiffness by also measuring inflammation from MRI exams (no difference was observed at any dose level) and various biomarkers related to senescent cells. In fact, the pain and function measurements using WOMAC consistently demonstrated that the placebo performed better than individuals taking any of the three lowest doses of UBX0101. It's important to note that "clinically meaningful" is not as high of a standard as "statistically significant." It's also important to note that based on the results published in the company's press release, there actually wasn't much of a dose-dependent response. Part A Results (One of Six Different Doses or Placebo)ĭose-dependent and clinically meaningful reduction at 12 weeks It's not quite the fountain of youth, and isolating individual circulating factors that can deliver a therapeutic benefit in something as complex as the human body will prove difficult, but it's certainly worth investigating. ![]() Studies have shown that exposing older mice to blood taken from younger mice can reduce and even reverse some of the effects of aging thanks to a cocktail of such proteins. Youth-circulating factors are exactly what they sound like: proteins ("factors") that circulate in the blood of younger organisms and drive regenerative processes. ![]() It's inevitable that science will investigate ways to control, transplant, or genetically engineer mitochondria for therapeutic benefit, and Unity Biotech is keen to become a pioneer in that area. Certain mutations or errors in mitochondrial DNA have been linked to everything from autism to cancer to aging. While mitochondria live within most cells, they actually retain their own unique genomes different from your own. Mitochondria produce chemical energy that can be readily used by cells they play an essential role in health. ![]()
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